PUBLICATIONS
2024
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Lipid metabolism is dysregulated in endocrine glands upon autoimmune demyelination. J Neuroimmunol. 2024 May 7:391:578366. Carver JJ, Pugh BA, Lau KM, Didonna A. PMID: 38733741.
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Autoimmune demyelination alters hypothalamic transcriptome and endocrine function. J Neuroinflammation. 2024 Jan 4;21(1):12. Carver JJ, Lau KM, Puckett AE, Didonna A. PMID: 38178091.
2023
High-resolution DNA methylation screening of the major histocompatibility complex in multiple sclerosis. Front Neurol. 2023 Dec 8:14:1326738. Ma Q, Augusto DG, Montero-Martin G, Caillier SJ, Osoegawa K, Cree BAC, Hauser SL, Didonna A, Hollenbach JA, Norman PJ, Fernandez-Vina M, Oksenberg JR. PMID: 38145128.
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Quantification of autoreactive antibodies in mice upon experimental autoimmune encephalomyelitis. J Vis Exp. 2023 Dec 1:(202). Carver JJ, Didonna A. PMID: 38108416.
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Cysteine carboxyethylation: a novel post-translational modification associated with autoimmune arthritis. Signal Transduct Target Ther. 2023 Jul 19;8(1):274. Didonna A. PMID: 37463891.
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Integration of epigenetic and genetic profiles identifies multiple sclerosis disease-critical cell types and genes. Commun Biol. 2023 Mar 30;6(1):342. Ma Q, Shams H, Didonna A, Baranzini SE, Cree BAC, Hauser SL, Henry RG, Oksenberg JR. PMID: 36997638.
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Ataxin-1 controls the expression of specific non-coding RNAs in B cells upon autoimmune demyelination. Immunol Cell Biol. 2023 Jan 22. Ma Q, Didonna A. PMID: 36681886.
2022
Epigenetic control of ataxin-1 in multiple sclerosis. Ann Clin Transl Neurol. 2022 Aug;9(8):1186-1194. Ma Q, Oksenberg JR, Didonna A. PMID: 35903875.
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Polygenic risk score association with multiple sclerosis susceptibility and phenotype in Europeans. Brain. 2022 Mar 7;awac092. Shams H, Shao X, Santaniello A, Kirkish G, Harroud A, Ma Q, MS-EPIC Team, Schaefer C, McCauley JL, Cree BAC, Didonna A, Baranzini SE, Patsopoulos NA, Hauser SL, Barcellos LF, Henry RG, Oksenberg JR. PMID: 35253861.
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Methylation at a conserved lysine residue modulates tau assembly and cellular functions. Mol Cell Neurosci. 2022 Feb 26;103707. Shams H, Matsunaga A, Ma Q, Mofrad MRK, Didonna A. PMID: 35231567.
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A short HLA-DRA isoform binds the HLA-DR2 heterodimer on the outer domain of the peptide-binding site. Arch Biochem Biophys. 2022 Feb 23;109156. Shams H, Hollenbach JA, Matsunaga A, Mofrad MRK, Oksenberg JR, Didonna A. PMID: 35218721.
2021
Specific hypomethylation programs underpin B cell activation in early multiple sclerosis. Proc Natl Acad Sci USA. 2021 Dec 21;118(51):e2111920118. Ma Q, Caillier SJ, Muzic S, University of California San Francisco MS-EPIC Team, Wilson MR, Henry RG, Cree BAC, Hauser SL, Didonna A, Oksenberg JR. PMID: 34911760.
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Pharmacological perturbation reveals deficits in D2 receptor responses in Thap1 null mice. Ann Clin Transl Neurol. 2021 Dec; 8(12):2302-2308. Frederick NM, Pooler MM, Shah P, Didonna A, Opal P. PMID: 34802187.
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The novel multiple sclerosis susceptibility gene ATXN1 regulates B cell receptor signaling in B-1a cells. Mol Brain. 2021 Jan 21; 14(1):19. Ma Q, Didonna A. PMID: 33478569.
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A splice acceptor variant in HLA-DRA affects the conformation and cellular localization of the class II DR alpha-chain. Immunology. 2021 Feb; 162(2):194-207. Didonna A, Damotte V, Shams H, Matsunaga A, Caillier SJ, Dandekar R, Misra MK, Mofrad MRK, Oksenberg JR, Hollenbach JA. PMID: 32986852.
2020
Oligodendrocyte-specific Argonaute profiling identifies microRNAs associated with experimental autoimmune encephalomyelitis. J Neuroinflammation. 2020 Oct 12; 17(1):297. Ma Q, Matsunaga A, Ho B, Oksenberg JR, Didonna A. PMID: 33046105.
Tau at the interface between neurodegeneration and neuroinflammation. Genes Immun. 2020 Nov; 21(5):288-300. Didonna A. PMID: 33011744.
Ataxin-1 regulates B cell function and the severity of autoimmune experimental encephalomyelitis. Proc Natl Acad Sci USA. 2020 Sep 22; 117(38):23742-23750. Didonna A, Canto Puig E, Ma Q, Matsunaga A, Ho B, Caillier SJ, Shams H, Lee N, Hauser SL, Tan Q, Zamvil SS, Oksenberg JR. PMID: 32878998.
TopoDB: a novel multifunctional management system for laboratory animal colonies. Database (Oxford). 2020 Jan 01; 2020. Renschen A, Matsunaga A, Oksenberg JR, Santaniello A, Didonna A. PMID: 33206961.
2019
Mitoma H. Manto M. (eds) Neuroimmune Diseases. Contemporary Clinical Neuroscience. Genetic Factors in Neuroimmune Diseases. 2019; 357-386. Didonna A, Cantó E.
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The role of neurofilament aggregation in neurodegeneration: lessons from rare inherited neurological disorders. Mol Neurodegener. 2019 May 16; 14(1):19. Didonna A, Opal P. PMID: 31097008.
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Sex-specific Tau methylation patterns and synaptic transcriptional alterations are associated with neural vulnerability during chronic neuroinflammation. J Autoimmun. 2019 Jul; 101:56-69. Didonna A, Cantó E, Shams H, Isobe N, Zhao C, Caillier SJ, Condello C, Yamate-Morgan H, Tiwari-Woodruff SK, Mofrad MRK, Hauser SL, Oksenberg JR. PMID: 31010726.
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Loss of the dystonia gene Thap1 leads to transcriptional deficits that converge on common pathogenic pathways in dystonic syndromes. Hum Mol Genet. 2019 Apr 15; 28(8):1343-1356. Frederick NM, Shah PV, Didonna A, Langley MR, Kanthasamy AG, Opal P. PMID: 30590536.
2018
Mutant ataxin1 disrupts cerebellar development in spinocerebellar ataxia type 1. J Clin Invest. 2018 Jun 01; 128(6):2252-2265. Edamakanti CR, Do J, Didonna A, Martina M, Opal P. PMID: 29533923.
Aberrant STAT phosphorylation signaling in peripheral blood mononuclear cells from multiple sclerosis patients. J Neuroinflammation. 2018 Mar 07; 15(1):72. Canto E, Isobe N, Didonna A, MS-EPIC Study Group , Hauser SL, Oksenberg JR. PMID: 29514694.
2017
The Genetics of Multiple Sclerosis. Multiple Sclerosis: Perspectives in Treatment and Pathogenesis. 2017 Nov 14; 3-16. Didonna A, Oksenberg JR. PMID: 29261259.
Hyperpolarized 13C MR metabolic imaging can detect neuroinflammation in vivo in a multiple sclerosis murine model. Proc Natl Acad Sci USA. 2017 Aug 15; 114(33):E6982-E6991. Guglielmetti C, Najac C, Didonna A, Van der Linden A, Ronen SM, Chaumeil MM. PMID: 28760957.
2016
Advances in Sequencing Technologies for Understanding Hereditary Ataxias: A Review. JAMA Neurol. 2016 Dec 01; 73(12):1485-1490. Didonna A, Opal P. PMID: 27749953.
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Immune cell-specific transcriptional profiling highlights distinct molecular pathways controlled by Tob1 upon experimental autoimmune encephalomyelitis. Sci Rep. 2016 Aug 22; 6:31603. Didonna A, Cekanaviciute E, Oksenberg JR, Baranzini SE. PMID: 27546286.
Preclinical Models of Multiple Sclerosis: Advantages and Limitations Towards Better Therapies. Curr Med Chem. 2016; 23(14):1442-59. Didonna A. PMID: 27048376.
2015
A non-synonymous single-nucleotide polymorphism associated with multiple sclerosis risk affects the EVI5 interactome. Hum Mol Genet. 2015 Dec 15; 24(24):7151-8. Didonna A, Isobe N, Caillier SJ, Li KH, Burlingame AL, Hauser SL, Baranzini SE, Patsopoulos NA, Oksenberg JR. PMID: 26433934.
Characterization of four new monoclonal antibodies against the distal N-terminal region of PrP(c). PeerJ. 2015; 3:e811. Didonna A*, Venturini AC*, Hartman K, Vranac T, Curin Å erbec V, Legname G. PMID: 25802800. *Equal contribution
Genetic determinants of risk and progression in multiple sclerosis. Clin Chim Acta. 2015 Sep 20; 449:16-22. Didonna A, Oksenberg JR. PMID: 25661088.
Post-translational modifications in neurodegeneration. AIMS Biophysics. 2015 Jan 1; 3(1):27-49. Didonna A, Benetti F.
The promise and perils of HDAC inhibitors in neurodegeneration. Ann Clin Transl Neurol. 2015 Jan; 2(1):79-101. Didonna A, Opal P. PMID: 25642438.
2014
The histone deacetylase HDAC3 is essential for Purkinje cell function, potentially complicating the use of HDAC inhibitors in SCA1. Hum Mol Genet. 2014 Jul 15; 23(14):3733-45. Venkatraman A*, Hu YS*, Didonna A*, Cvetanovic M*, Krbanjevic A*, Bilesimo P, Opal P. PMID: 24594842. *Equal contribution
2013
Giant axonal neuropathy-associated gigaxonin mutations impair intermediate filament protein degradation. J Clin Invest. 2013 May; 123(5):1964-75. Mahammad S, Murthy SN, Didonna A, Grin B, Israeli E, Perrot R, Bomont P, Julien JP, Kuczmarski E, Opal P, Goldman RD. PMID: 23585478.
Prion protein and its role in signal transduction. Cell Mol Biol Lett. 2013 Jun; 18(2):209-30. Didonna A. PMID: 23479001.
2012
The role of Bax and caspase-3 in doppel-induced apoptosis of cerebellar granule cells. Prion. 2012 Jul 01; 6(3):309-16. Didonna A, Sussman J, Benetti F, Legname G. PMID: 22561161.
2011
Infrared microspectroscopy: a multiple-screening platform for investigating single-cell biochemical perturbations upon prion infection. ACS Chem Neurosci. 2011 Mar 16; 2(3):160-74. Didonna A*, Vaccari L*, Bek A, Legname G. PMID: 22778865. *Equal contribution
2010
Aberrant ERK 1/2 complex activation and localization in scrapie-infected GT1-1 cells. Mol Neurodegener. 2010 Aug 09; 5:29. Didonna A, Legname G. PMID: 20696038.